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n 1939, a notable medical case occurred when a woman experienced blistering on her lips after biting into a mango. Her reaction was strikingly similar to that caused by poison ivy, prompting doctors to investigate a botanical connection.

Mango skin, not the pulp, harbors urushiol. This is the same allergenic compound responsible for the irritating effects of poison ivy, poison oak, and poison sumac.

This cross-reactivity can lead some individuals to develop itchy rashes, small blisters, or linear marks on their skin after handling mangoes, mimicking poison ivy dermatitis.

A study in 2005 provided further observations. Seventeen Americans, all with known prior reactions to poison ivy, developed dermatitis after their first contact with mangoes.

However, not everyone who is sensitive to poison ivy will react to mangoes. Immunity might develop through dietary exposure, especially in regions where mangoes and other urushiol-containing foods are commonly consumed.

Sources: PubMed, IJHSR Case Report, Forum Health Clarkston, Pharmacy Times

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